The formalism of Baier-Dokshitzer-Mueller-Peigné-Schiff and Zakharov determines modifications of parton splittings in the QCD plasma that arise from medium-induced gluon radiation. Here, we extend this BDMPS-Z formalism to medium-modifications of the gluon splitting into a quark–anti-quark pair. We derive a compact path-integral formulation that resums effects from an arbitrary number of interactions with the medium. Analyses in the $N=1$ opacity and the saddle point approximations reveal two phenomena: a medium-induced momentum broadening that increases the invariant mass of quark–anti-quark pairs, and a medium-enhanced production of such pairs. We note that both effects are numerically sizeable if the average momentum transfer from the medium is comparable to the quark mass. In ultra-relativistic heavy-ion collisions, this condition is satisfied for charm quarks. We therefore focus our numerical analysis on the medium-modification of $g\to c\bar{c}$, although our derivation applies equally well to $g\to b \bar{b}$ and to gluons splitting into light-flavoured quark–anti-quark pairs.