We exploit the concept of hydrodynamic attractors to establish a general relation between the initial state energy and the produced particle multiplicities in high-energy nuclear collisions. When combined with an ab initio model of energy deposition, the entropy production during the pre-equilibrium phase naturally explains the universal centrality dependence of the measured charged particle yields in nucleus-nucleus collisions. We further estimate the energy density of the far-from-equilibrium initial state and discuss how our results can be used to constrain non-equilibrium properties of the quark-gluon plasma.